Professor and Foundation Fellow, Department of Molecular and Cellular Biology Kennesaw State University
"Prokaryotic Noxes: Bigger Hammers for Structure-function Basics"
The Smith lab research centers around the mechanisms that control the activities of proteins that participate in cell signaling. She uses evolutionary comparisons of protein sequences and molecular modeling to predict the parts of proteins most likely to control their activity. And then she tests those predictions in the laboratory, using a combination of techniques to perturb and measure activity. She investigates the structure, function and control of NADPH oxidases (Nox) and of voltage-gated proton channels (HV1). Noxes and HV1 are known to work together in several cell types, and both produce signals important not only to human health but also to the development, physiology, and lifestyles of many other organisms.