Uncovering a Hidden Protein “Tail” that Puts the Brakes on Cell Signaling

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Georgia Tech Associate Professor Matthew Torres and Doctoral Candidate Shilpa Choudhury are shown with images showing cells with a localized green fluorescent protein signal at the membrane. (Credit: Rob Felt, Georgia Tech)

Georgia Tech Associate Professor Matthew Torres and Doctoral Candidate Shilpa Choudhury are shown with images showing cells with a localized green fluorescent protein signal at the membrane. (Credit: Rob Felt, Georgia Tech)

Images of yeast cells responding to a pheromone stimulus in which the G gamma brake system is intact (left) or genetically turned off (right). In both images, the green color indicates the location of the effector protein that accumulates at the cellular membrane as a result of the stimulus, and was achieved by genetically tagging the effector protein with green fluorescent protein (GFP). (Credit: Shilpa Choudhury)