Roadmap for Advanced Cell Manufacturing Shows Path to Cell-Based Therapeutics

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Image shows adult human fibroblast cells with intracellular proteins involved in adhesion of these cells to an extracellular matrix. Magenta represents actin stress fibers in a cell and green staining represents a focal adhesion protein vinculin, which together contribute to how strongly these cells adhere to a matrix surface. Blue is the nucleus of a cell. These fibroblasts are converted to human induced pluripotent stem cells through a reprogramming process during which restructuring of the adhesion proteins takes place. (Image courtesy of Ankur Singh)

Close-up image shows the microfluidic device used by Georgia Tech researchers to capture cancer cell clusters in blood samples. The fluid shown in the device is a colored liquid designed to simulate the appearance of blood. (Credit: Rob Felt, Georgia Tech)

Image shows a close-up view of a microfluidic device that exploits the differences in adhesion strength between derived stem cells and contaminating cell types in a heterogeneous culture to selectively isolate cells of interest using fluid shear forces. Georgia Tech researchers designed the technique to separate the cells. (Georgia Tech Photo: Gary Meek)