Researchers Develop Method to Create 3D ‘Map’ of Tissue Structure and Function

Related Images

News Image Block

Three-dimensional molecular map of a tonsil using TOF-SIMS, a 3D chemical imaging technique that visualizes metabolic and cellular profiles of more than 190 compounds from a human tissue sample. The plot depicts four distinct chemical and protein signatures — lipids, metabolites, and isotope-labeled cells (CD20). (Image Courtesy: Ahmet Coskun)

A conceptual diagram illustrates how researchers used a single imagining technique called TOF-SIMS, or time-of-flight secondary ion mass spectrometry, to capture metabolic and cellular profiles of more than 190 compounds in human tissue samples. Ahmet Coskun’s research team used tools from data science to turn all of that data into a 3D map of the tonsil tissue. Their technique is reported in Science Advances. (Image Courtesy: Ahmet Coskun)

Ahmet Coskun, Bernie Marcus Early Career Professor