Cheng Zhu

Regents' Professor
Office Location: 
UAW 1210
Title 2: 
J. Erskine Love Endowed Chair, Engineering
Title 3: 
Executive Director, International Programs
Research Interests: 

Biomechanics and mechanobiology of cell adhesion and signaling molecules of the immune system and the vascular systems:

Our interests lie in the adhesion and signaling molecules of the immune system as well as those involved in platelet adhesion and aggregation. We are primarily focused on early cell surface interaction kinetics and their primary signaling responses, as these are critical in determining how a cell will ultimately respond upon contact with another cell. The majority of our work ranges from single molecule interaction studies using atomic force microscopy, molecular dynamics simulations, or biomembrane force probe assays to single cell studies using micropipette adhesions assays, fluorescence imaging techniques, or real-time confocal microscopy. These assays focus on the mechanics and kinetics of receptor-ligand binding and their downstream signaling effects within cells. T cell receptors, selectins, integrins, and their respective ligands are some of the cell surface molecules currently under investigation in our lab. Understanding the initial interaction between molecules such as these and their subsequent early signaling processes is crucial to elucidating the response mechanisms of these physiological systems. Ultimately, our research strives to help better understand the mechanisms within these systems for possible medical applications in autoimmunity, allergy, transplant rejection, and thrombotic disorders. 

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Grant Affiliations: 
Cellular & Tissue Engineering
Research Areas: 
Molecular, Cellular and Tissue Biomechanics
Research Center Affiliations: 
Regenerative Engineering and Medicine (REM)
Integrated Cancer Research Center
Center for ImmunoEngineering
Georgia Institute of Technology
Petit Roles: 
Petit Faculty Member
Primary School/Department: 
Wallace H. Coulter Department of Biomedical Engineering