Our research focuses on LC-MS based proteomics and its biomedical applications. Novel MS based methods are being developed to characterize proteins, especially protein post-translational modifications (PTMs). MS-based large-scale analysis can systematically identify and quantify proteins and their PTMs for the different states of cells or tissues, such as cancerous samples. This may provide a better understanding of the function of proteins, the role that proteins play in physiological and pathological processes, cell signaling, cell metabolism, and the relationship between proteins and cancer.
We are interested in understanding the genetic basis of heritable behavioral variation. In the current age, it has become cheap and easy to catalog the set of genetic differences between two individuals. But which genetic differences are responsible for generating differences in innate behaviors, including liability to neurological diseases such as autism, bipolar disease, and schizophrenia? How do these causative genetic variants modify a nervous system? Besides their role in disease, genetic variation is the substrate for natural selection. To understand how behavior evolves, we must understand how it varies.
Development of metal specific fluorescent probes, mechanistic study of metalloprotein catalyzed reactions with unusual coordination geometries, development of protein-based, semisynthetic organometallic catalysts in aqueous solution
My training is as a clinical prosthetist and as such my research interests surround all aspects of amputation, provision of external prostheses (artificial limbs) to individuals, how people adapt to amputation and how they incoporate an artificial body part into their activities of daily living and body image. In the next 5 - 10 years, prostheses will transform from entirely external devices that someone slips or straps on into something that is both invasive and external. Oseointegrated implantation for suspension of prostheses, already a reality, will become approved in the US and this is an area in which I have terrific interest. Furthermore, control of the next generation of artificial limbs will be achieved through impantable electrodes and peripheral nerve connections. As these technologies are developed, I aim to serve as the clinical specialist who will facilitate the translation of these technologies to their application in people.