I am interested in understanding (i) how transcription factors find their targets on DNA and activate transcription despite the presence of nucleosomes and (ii) how structural details of trans-activators and cis-elements quantitatively fine-tune gene regulation at the cellular level.
Dr. Jang's research interest is to characterize and design nanoscale systems based on the molecular architecture-property relationship using computations and theories, which are especially relevant to designing new biomaterials for drug delivery and tissue engineering. Currently, he is focusing on 1) NanoBio-mechanics for DNA, lipid bilayer, and hydrogel systems; 2) Molecular interaction of Alzheimer proteins with various small molecules. Dr. Jang is also interested in various topics such as nanoelectronics, nanostructured energy technologies for fuel cell, battery and photovoltaic devices.
Cardiac and skeletal muscle excitation-contraction coupling;regulation of ryanodine receptor calcium release channels by endogenous effectors; single channel electrophysiology; muscle aging, fatigue and disease.
Our laboratory focuses on the smallest organisms on the planet, the bacteria and the archaea, which represent the largest reservoir of biodiversity on Earth, drive the life-sustaining biogeochemical cycles, and cause or control diseases in humans, animals, and plants. Our scientific interests are at the interface of microbial ecology with engineering and computational biology. The long-term goals of our research is to broaden understanding of the genetic and metabolic diversity of the microorganisms and to explore this biodiversity for biotechnological applications.
Research integrates my work in complex fluids and granular media and the biomechanics of locomotion of organisms and robots to address problems in nonequilibrium systems that involve interaction of matter with complex media.