Cardiac and skeletal muscle excitation-contraction coupling;regulation of ryanodine receptor calcium release channels by endogenous effectors; single channel electrophysiology; muscle aging, fatigue and disease.
Chemical biology, immunology, and evolution with viruses. Engineered polyvalency in biologically active structures. Development of reactions for organic synthesis and materials science. Traditional and combinatorial synthesis of biologically active compounds. New functional polymeric materials and surfaces.
Our research focuses on LC-MS based proteomics and its biomedical applications. Novel MS based methods are being developed to characterize proteins, especially protein post-translational modifications (PTMs). MS-based large-scale analysis can systematically identify and quantify proteins and their PTMs for the different states of cells or tissues, such as cancerous samples. This may provide a better understanding of the function of proteins, the role that proteins play in physiological and pathological processes, cell signaling, cell metabolism, and the relationship between proteins and cancer.
We are interested in understanding the genetic basis of heritable behavioral variation. In the current age, it has become cheap and easy to catalog the set of genetic differences between two individuals. But which genetic differences are responsible for generating differences in innate behaviors, including liability to neurological diseases such as autism, bipolar disease, and schizophrenia? How do these causative genetic variants modify a nervous system? Besides their role in disease, genetic variation is the substrate for natural selection. To understand how behavior evolves, we must understand how it varies.