Cellular and tissue engineering; genetic engineering of cells for tissue engineering applications; cell encapsulation; magnetic resonance monitoring of tissue constructs; cryopreservation; mathematical modeling of cells and tissues.
Physiological and biomechanical mechanisms underlying fine motor skills and their adjustments and adaptations to heightened sympathetic nerve activity, aging or inactivity, space flight or microgravity, neuromuscular fatigue, divided attention, and practice in humans. He uses state-of-the-art techniques in neuroscience, physiology, and biomechanics (e.g., TMS, EEG, fMRI, single motor unit recordings, microneurography, mechanomyography, ultrasound elastography, and exoskeleton robot) in identifying these mechanisms.
Our research focuses on the host-pathogen relationship and uses 1) host genetic studies of infectious diseases (tuberculosis, leprosy, Buruli ulcer) and 2) molecular systems biology studies of nano-vesicular exosomes released from stimulated immune subsets.
I am interested in understanding (i) how transcription factors find their targets on DNA and activate transcription despite the presence of nucleosomes and (ii) how structural details of trans-activators and cis-elements quantitatively fine-tune gene regulation at the cellular level.