Molecular physiology of ion channels and receptors, with emphasis on epithelial chloride channels. Our specific focus is the pathophysiology of Cystic Fibrosis, including the structure/function of CFTR and its many roles in the airway.
The David G. Lynn Group at Emory University works to understand the structures and forces that enable supramolecular self-assembly, how chemical information can be stored and translated into new molecular entities, and how the forces of evolution can be harnessed in new structures with new function. Some of our current research areas include the origins of prokaryotic and eukaryotic pathogenesis, template directed polymerization and dynamic combinatorial systems, amyloid diseases and protein self-assembly, and intelligent materials.
Finn's laboratory combines basic research and clinical investigation, focusing on translational research in the area of atherosclerotic coronary artery disease, including mechanisms of disease, treatment, and exposing potential treatment complications. Currently, his research focuses on three major areas: 1) the effect of drug eluting stents on re-endothelialization of stent surfaces, particularly molecular mechanisms of vascular healing after injury; 2) the role of angiogenesis and intraplaque hemorrhage in coronary plaque progression and inflammation; and 3) the pathophysiology of coronary lesion progression in type 2 diabetics. The Finn lab makes use of both animal models and clinical trials to provide insights into mechanisms of disease and treatment which can be translated directly into the care of patients.
Dr. Nicholas Boulis, MD is a Functional Neurosurgeon with significant expertise in the field of gene transfer to the nervous system. Dr. Boulis' Gene and Cell Therapy Translational Laboratory pursues advanced biological treatments for neurological disorders, including Amyotrophic Lateral Sclerosis (ALS, also known as Lou Gehrig's disease) and Spinal Muscular Atrophy (SMA).
The Yoon Lab has been working on stem cell research in various cardiovascular diseases. Our major research interest is to use stem cell technology to treat various cardiovascular diseases, and we have been developing and using different bone marrow-derived stem sell or progenitor cells for cardiovascular repair.
Dr. Oshinski is well known for his collaborative efforts between Emory and Georgia Tech's Department of Biomedical Engineering, along with his dedication to advancing the technologies of MR imaging. One area of concentration is the development of Cardiovascular MRI for clinical and basic science applications. Dr. Oshinski has worked on development of the contrast-enhanced MRA and phase-contrast MR for rapid assessment of the aorta and the peripheral runoff vessels. He also Implemented SSFP cine imaging for rapid breath-hold assessment of cardiac function, IR recovery sequences for myocardial perfusion imaging, and creating a protocol for using MR coronary angiography to diagnose the proximal course of the coronary arteries.
Cleft and craniofacial disorders are my primary clinical and basic research interests. Even though the surgical repair of cleft lip and palate is highly effective, patients will continue to be faced with ongoing medical, dental, and surgical care. Surgical outcomes can be variable, and the patient's facial growth and development is primarily the result of their genetic composition. Therefore, much of my research focuses on the problems that can develop during the years that follow surgery.
Neuroimaging, neurostimulation, rehabilitation, neural plasticity, motor learning, stroke
My research interests are centered on understanding the adaptive capacity of the human nervous system in order to create innovative rehabilitation interventions to ameliorate disability and improve quality of life for individuals with neurologic impairment. My research laboratory is focused on translational neurorehabilitation in a highly collaborative atmosphere. Transdisciplinary collaborations are embraced at every opportunity in an effort to inform our work and contribute to the activities of other scientists. I also see these collaborations as a fertile training ground for students in the lab that come from neuroscience, medicine, biomedical engineering, physical therapy, computer science, etc.
The overall research of the lab focuses on a systems integration approach to musculoskeletal disease and regenerative engineering by applying novel imaging and engineering approaches to mechanistic biology problems. Our current work has three main thrusts: (i) cell and biologic therapies for the healing of large bone and muscle defects, (ii) multi-scale mechanical regulation of bone regeneration, (iii) intra-articular therapeutic delivery for post-traumatic osteoarthritis. Combining backgrounds in mechanical engineering, vascular biology and musculoskeletal tissue regeneration, our research integrates mechanics principles and analytical tools with molecular biology techniques to uniquely address challenges of musculoskeletal disease and regeneration.