An engineer by training, Dr. Padala is currently focused on studying the biomechanics and mechanobiology of heart valve disease and heart failure. He received his BS in mechanical engineering from Osmania University in India in 2004, and an MS in mechanical engineering and PhD in bioengineering from Georgia Tech in 2010. Since joining Emory and establishing his independent laboratory in 2010, his focus has been on studying in-vivo heart valve and cardiac mechanics in pre-clinical models. In 2012, he spent one year at Imperial College London on a Leducq Fondation Career Development Award. He trained under Prof. Sir. Magdi Yacoub, a pioneer in cardiac transplantation and heart valve tissue engineering.
Heart Failure, Cardiac Valve Disease, Cardiovascular Devices, Cell and Gene Therapy, Tissue Engineering of Heart Valves
My laboratory is interested in the pathogenesis of heart valve disease and its impact on the onset and progression of heart failure. We use rodent and swine models of heart valve regurgitation, to understand the changes in the myocardial remodeling at multiple scales. Our recent work is also focused on linking functional changes in the myocardium to detectable genomic, transcriptomic, proteomic, and metabolomic changes, and investigate the potential of using their relationship for early detection of heart failure. Some of our work also involves developing new medical devices and technologies to repair heart valves and associated heart failure.
Finn's laboratory combines basic research and clinical investigation, focusing on translational research in the area of atherosclerotic coronary artery disease, including mechanisms of disease, treatment, and exposing potential treatment complications. Currently, his research focuses on three major areas: 1) the effect of drug eluting stents on re-endothelialization of stent surfaces, particularly molecular mechanisms of vascular healing after injury; 2) the role of angiogenesis and intraplaque hemorrhage in coronary plaque progression and inflammation; and 3) the pathophysiology of coronary lesion progression in type 2 diabetics. The Finn lab makes use of both animal models and clinical trials to provide insights into mechanisms of disease and treatment which can be translated directly into the care of patients.
The David G. Lynn Group at Emory University works to understand the structures and forces that enable supramolecular self-assembly, how chemical information can be stored and translated into new molecular entities, and how the forces of evolution can be harnessed in new structures with new function. Some of our current research areas include the origins of prokaryotic and eukaryotic pathogenesis, template directed polymerization and dynamic combinatorial systems, amyloid diseases and protein self-assembly, and intelligent materials.
The Xu laboratory is focusing on human cardiomyocytes derived from pluripotent stem cells, which hold promise for cardiac cell therapy, disease modeling, drug discovery, and the study of developmental biology. The laboratory is also collaborating with investigators in Georgia Tech, Emory University, and Children's Healthcare of Atlanta, exploring the application of nanotechnology and tissue engineering in stem cell research.
The Yoon Lab has been working on stem cell research in various cardiovascular diseases. Our major research interest is to use stem cell technology to treat various cardiovascular diseases, and we have been developing and using different bone marrow-derived stem sell or progenitor cells for cardiovascular repair.
Dr. Nicholas Boulis, MD is a Functional Neurosurgeon with significant expertise in the field of gene transfer to the nervous system. Dr. Boulis' Gene and Cell Therapy Translational Laboratory pursues advanced biological treatments for neurological disorders, including Amyotrophic Lateral Sclerosis (ALS, also known as Lou Gehrig's disease) and Spinal Muscular Atrophy (SMA).
Dr. Oshinski is well known for his collaborative efforts between Emory and Georgia Tech's Department of Biomedical Engineering, along with his dedication to advancing the technologies of MR imaging. One area of concentration is the development of Cardiovascular MRI for clinical and basic science applications. Dr. Oshinski has worked on development of the contrast-enhanced MRA and phase-contrast MR for rapid assessment of the aorta and the peripheral runoff vessels. He also Implemented SSFP cine imaging for rapid breath-hold assessment of cardiac function, IR recovery sequences for myocardial perfusion imaging, and creating a protocol for using MR coronary angiography to diagnose the proximal course of the coronary arteries.
Dr. Arbiser's research focuses on the regulation of angiogenesis and tumorigenesis by signal transduction pathways. Our laboratory has chosen three model systems to study these relationships. The first area is the common vascular birthmarks of children and their malignant counterparts, angiosarcomas. The second application of these studies are benign neoplasms which develop in the autosomal dominant syndrome tuberous sclerosis (TS). The third application of these studies is in the pathogenesis of malignant melanoma. Dr Arbiser has developed the hypothesis that oncogenes disrupt the balance between angiogenesis stimulators and inhibitors.
I have 2 areas of ongoing investigation. One focus is a C-type lectin-family receptor (CD303) expressed uniquely on the surface of human plasmacytoid dendritic cells. Data suggest that this receptor impacts function of these cells in innate and adaptive immunity. We have developed unique biochemical tools to better understand the structure and function of CD303 including identification of natural binding targets whether of self or non-self origin. Specific efforts focus on identifying the specific counter-receptors on these targets and better characterizing the impact of receptor-ligand engagement. A second focus involves deciphering the role of the Bcl-6 interacting transcriptional co-repressor MTA3 and BCL6 in B cell lymphomas, work done in collaboration with Dr. P. Wade at NIEHS, and translating this knowledge into diagnostically useful tools.