Molecular, Cellular and Tissue Biomechanics

J. Brandon Dixon


 

Research Keywords:

biomechanics optics fluorescence lymphatics lipid transport lymphedema microfluidics in-vivo imaging

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biomechanics, biomedical optics, fluorescence, lymphatics, lipid transport, lymphedema, microfluidics, in-vivo imaging

Susan Thomas


 

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Immunoengineering, Cancer, Metastasis, Immunotherapy, Drug delivery

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Incorporating mechanics with cellular engineering, biochemistry, biomaterials, and immunology to 1) elucidate how physical forces regulate seemingly unrelated aspects of cancer such as metastasis and immune suppression as well as 2) develop novel immunotherapeutics to treat cancer.

Craig Forest


 

Research Keywords:

Neuroengineering tools and robotics, ultra-high throughput genomics and molecular measurement instrumentation; 3-D microfabrication and bioMEMS technologies for neuroscience and genomics applications; and micro-lenslet arrays

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Neuroengineering, ultra-high throughput genomics instrumentation; detection, separation, amplification of DNA; 3-D microfabrication technologies for genomics applications; and micro-lenslet arrays

Robert Guldberg


 

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Cell-based Therapies, Biomaterials, Biomechanics, Micro-CT Imaging

Todd Sulchek


 

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Bioengineering and Microelectromechanical Systems: Atomic force microscopy, pathogen adhesion and endocytosis, cell biomechanics, single molecule biophysics, drug delivery and targeting, cell membrane mimetics, biosensors

Wilbur Lam


 

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Cellular Mechanics, BioMEMs/microfabrication/microfluidics, hematology (platelet and leukocyte biology, sickle cell disease, thrombosis), Endothelial cell biology, Cancer, Pediatric Medical Devices and Diagnostics

Andrés García


 

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Biomolecular, cellular, and tissue engineering strategies to direct cell function for biomaterial and regenerative medicine applications

Cheng Zhu


 

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Bioengineering; Biomechanics of single cells and single molecules, cell adhesion kinetics, and bio-MEMS

Raquel Lieberman


 

Research Keywords:

structural biology, protein misfolding, amyloid, glaucoma, crystallography, molecular biophysics

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The Lieberman research group focuses on biophysical and structural characterization of proteins involved in misfolding disorders. One major research project in the lab has been investigations of the glaucoma-associated myocilin protein. The lab has made major strides toward detailed molecular understanding of myocilin structure, function, and disease pathogenesis. Our research has clearly demonstrated similarities between myocilin glaucoma and other protein misfolding disorders, particularly amyloid diseases. The work has led to new efforts aimed at ameliorating the misfolding phenotype using chemical biology approaches. Our second project involves the study of membrane-spanning proteolytic enzymes, which have been implicated disorders such as Alzheimer disease. Our group is tackling questions surrounding discrimination among and presentation of transmembrane substrates as well as the enzymatic details of peptide hydrolysis. In addition to the biochemical characterization of intramembrane aspartyl proteases, our group is developing new crystallographic tools to improve the likelihood of determining structures of similarly challenging membrane proteins more generally. 

Seung Jang


 

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Dr. Jang's research interest is to characterize and design nanoscale systems based on the molecular architecture-property relationship using computations and theories, which are especially relevant to designing new biomaterials for drug delivery and tissue engineering. Currently, he is focusing on 1) NanoBio-mechanics for DNA, lipid bilayer, and hydrogel systems; 2) Molecular interaction of Alzheimer proteins with various small molecules. Dr. Jang is also interested in various topics such as nanoelectronics, nanostructured energy technologies for fuel cell, battery and photovoltaic devices.

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