Chemical Biology

Johnna Temenoff


 

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Development of novel polymeric biomaterials, Regeneration of tendon/ligament, Protein delivery for orthopaedic tissue engineering

Melissa Kemp


 

Research Keywords:

modeling

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Computational Biochemical Network Modeling, Role of Oxidative Stress in Immunology and Cancer, Signal Transduction, Proteomic Technologies

Robert Guldberg


 

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Cell-based Therapies, Biomaterials, Biomechanics, Micro-CT Imaging

Andrés García


 

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Biomolecular, cellular, and tissue engineering strategies to direct cell function for biomaterial and regenerative medicine applications

Mark Styczynski


 

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Systems biology, bioinformatics, metabolism, and metabolomics

Athanassios Sambanis


 

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Cellular and tissue engineering; genetic engineering of cells for tissue engineering applications; cell encapsulation; magnetic resonance monitoring of tissue constructs; cryopreservation; mathematical modeling of cells and tissues.

Manu Platt


 

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Tissue remodeling in regenerative medicine; Microenvironmental cues modulating stem cell signaling networks

Hang Lu


 

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Microfluidics; bioMEMS; behavior neuroscience; cell biology; automation and high throughput engineering approaches to biology and biotechnology, Regenerative Medicine

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Microfluidics; bioMEMS; behavior neuroscience; cell biology; automation and high throughput engineering approaches to biology and biotechnology

Raquel Lieberman


 

Research Keywords:

structural biology, protein misfolding, amyloid, glaucoma, crystallography, molecular biophysics

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The Lieberman research group focuses on biophysical and structural characterization of proteins involved in misfolding disorders. One major research project in the lab has been investigations of the glaucoma-associated myocilin protein. The lab has made major strides toward detailed molecular understanding of myocilin structure, function, and disease pathogenesis. Our research has clearly demonstrated similarities between myocilin glaucoma and other protein misfolding disorders, particularly amyloid diseases. The work has led to new efforts aimed at ameliorating the misfolding phenotype using chemical biology approaches. Our second project involves the study of membrane-spanning proteolytic enzymes, which have been implicated disorders such as Alzheimer disease. Our group is tackling questions surrounding discrimination among and presentation of transmembrane substrates as well as the enzymatic details of peptide hydrolysis. In addition to the biochemical characterization of intramembrane aspartyl proteases, our group is developing new crystallographic tools to improve the likelihood of determining structures of similarly challenging membrane proteins more generally. 

Julia Babensee


 

Research Keywords:

Biomaterials, Immunoengineering, Dendritic Cells

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Host responses to combination products, Biomaterial interactions with dendritic cells, Tissue engineering for rheumatoid arthritis, Targeted DNA vaccine delivery, Biomaterial-applied immunology

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