How Communication Among Cells Affects Development of Multicellular Tissue

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An agent-based computational model simulates the progression of intracellular molecular gradients and resultant differentiation patterns that emerge within a multicellular system. (Credit: Chad Glen, Georgia Tech)

Image shows colony patterning and morphology after 24 and 48 hours of retinoic acid exposure, respectively, with adenylyl cyclase or gap junction inhibition compared to the vehicle control.  (Credit: Chad Glen, Georgia Tech)

A sequence of images depicts the photo bleaching (frame 2) and recovery (frames 3-4) of a fluorescent dye for quantification of relative diffusion rates between adjacent stem cells within a colony. (Credit: Chad Glen, Georgia Tech)