The Foundation seeks to support one-to-two year grants that will develop new or improved tools to identify mitochondrial biomarkers for Parkinson's disease. The specific goals of this initiative are to facilitate the discovery and development of mitochondrial biomarkers for:
- Assess PD diagnosis, disease progression, and/or patient stratification; and
- Identify mitochondrial readouts that would inform therapeutic efficacy and target engagement, or
- Uncover novel mitochondrial targets relevant to PD.
Our understanding of mitochondrial dysfunction in PD has been largely dependent on pre-clinical models. Our goal is to expand on these discoveries and apply the knowledge gained through these studies to human biospecimens. The purpose of the Mitochondrial Biomarkers RFA is to seek proposals that focus on human biospecimen-derived data to identify relevant PD biomarkers that would inform disease diagnosis, disease progression, patient stratification, and/or pharmacodynamic readouts.