Melissa Kemp


Melissa

 

Kemp

Associate Professor
Primary School/Department: 
Wallace H. Coulter Department of Biomedical Engineering
Title 2: 
Georgia Cancer Coalition Distinguished Cancer Scholar

Phone: 
404-385-6341
Office Location: 
EBB 3019
University: 
Georgia Institute of Technology

Research Affiliations:

Research Center Affiliations: 
Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M)
Regenerative Engineering and Medicine (REM)
Integrated Cancer Research Center
Immunoengineering
Emergent Behavior of Integrated Cellular Systems
Center for ImmunoEngineering
Center for Integrative Genomics
Center for Pediatric Innovation (CPI)

Research Areas:

Research Areas: 
Cancer Biology
Chemical Biology
Stem Cell Technology
Systems Biology

Research Interests:

Systems biology, computational modeling, redox metabolism and signal tranduction. 

The Kemp Lab is focused on understanding how metabolism influences the decisions that cells make. Aging, stem cell differentiation, cancer metastasis, and inflammation rely on progressive changes in metabolism resulting in increased levels of reactive oxygen species. Collectively, the accumulation of these molecules is known as cellular oxidation, and pathological levels are referred to as oxidative stress. Our lab develops systems biology tools for investigating how cellular oxidation influences cellular fate and interpretation of cues from the extracellular environment. We are interested in the collective behavior that arises during stem cell differentiation, immune cell responses, or drug treatments from metabolic diversity in individual cells. Because of the numerous biochemical reactions involved, we develop computational models and analytical approaches to understand how complex protein network properties are influenced by redox-sensitive proteins; these proteins typically have reactive thiol groups that are post-translationally regulated in the presence of reactive oxygen species to alter activity and/or function. Experimentally, we develop novel high-throughput single cell techniques for the detection and quantification of intracellular oxidation.