John W. Henson, M.D.
Whitaker Endowed Chair in Oncology Services
“BRCAness in Malignant Gliomas: Missing the IDH Story”
Mutation of the isocitrate dehydrogenase gene in brain tumors appeared to be an odd finding in 2008. A decade later, the story of a neomorphic enzyme, its oncometabolite, and resulting BRCAness offers ideas for new treatments.